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The abbreviation used to indicate "hours of sleep" or "bedtime" in medication administration is "HS" or "qhs." This abbreviation comes from the Latin term "hora somni," which translates to "hour of sleep." It is commonly used in medical prescriptions to specify that a medication should be taken at bedtime or during the night, aligning with the patient’s sleep schedule.

This terminology is particularly important for healthcare professionals, including medication aides and caregivers, as it helps ensure that medications are administered at the appropriate times to maximize effectiveness and adhere to prescribed routines. The other options, while also used in medication administration, refer to different timing for doses: "qd" means "once a day," "bid" means "twice a day," and "pc" means "after meals." Each of these is tailored to specific patient needs and dosing schedules, but they do not convey the same information regarding bedtime or sleep.